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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Palmer, K. O.; Young, Lauriann E.
Author Affiliation, Ana.
Department of Basic Medical Sciences
Article Title
The Effect of Oestrogen on Discriminative Learning and Memory in Aged Male and Female Rats
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
West Indian Medical Journal
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2004
Volume ID
53
Issue ID
Suppl. 5
Page(s)
19
Language
n/a
Connective Phrase
n/a
Location/URL
n/a
ISSN
0043-3144 WIMJAD
Notes
n/a
Abstract
Objective: To compare the relative effects of oestrogen on configural discriminative learning and memory in aged male and female rats. Method: Eighteen 30 month- old male rats were assigned to three treatment groups (group, n = 6), viz: oestradiol, anastrozole (an aromatase inhibitor) and oil; and compared with non-treated aged male (n = 12) and female (n = 12) controls. Animals were trained in an operant system, utilizing a negativ patterning discriminative learning task. Rats learned to press a lever when a single stimulus (light or tone ) was presented and avoid pressing when both stimuli were simultaneously presented. upon attainment of 75& correct performance rate, controls were either orchidectomized or ovariectomized. Memory was assessed in all groups following a period of two weeks. Data were analyzed using SPSS version 11.5....
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