Bazuaye, P. E.; Fletcher, Horace M.; Smikle, Monica ; Jackson, Maria D.; McFarlane-Anderson, Norma
Author Affiliation, Ana.
Department of Community Health and Psychiatry
Class 1 HLA-A-B Haplotypes and Tumour Factors (TNF-à) - 308 Polymorphism and Cervical Dysplasia [Abstract]
West Indian Medical Journal
Date of Publication
54 Suppl. 2
Presented at the Caribbean Health Research Council, Tobago
Objective: To determine whether class 1 HLA-A, -Band TNF-à genetic variants are associated with cervical dysplasia. Method: subjects were genotyped for (1) HLA class 1 A & B (CIN III cancer = 68, controls = 88) and (2) TNF-à (CIN I, II, III, cancer = 240, controls = 102). Methods: Subjects were genotyped for (1) HLA class 1 A & B (CIN III and cancer = 68, controls = 88) and (2) TNF-à (CIN I, II, III, cancer = 240, controls = 102). Conclusion: TNF-à SNP-308 in this population is asociated with cervical dysplasia independent of the class I-A-B MHC genes/haplotypes.....