Smikle, Monica .; Christian, Nicole; DeCeulaer, Karel; Barton, Everard N.; Roye-Green, Karen J.; Dowe, Gwendolyn; McFarlane-Anderson, Norma; Nicholson, G. D.
Author Affiliation, Ana.
Department of Microbiology
HLA-DRB Alleles and Systemic Lupus Erythematosus in Jamaicans
Southern Medical Journal
Date of Publication
BACKGROUND: The human leukocyte antigens (HLA) are associated with susceptibility to systemic lupus erythematosus (SLE) and manifestations of SLE in different ethnic groups. METHODS: A DNA-based HLA-typing method was used to determine alleles of HLA-DRB1, DRB3, DRB4 and DRB5 in Jamaican patients. A total of 70 patients and 100 control subjects were studied. RESULTS: HLA-DRB3*01/03 was significantly associated with susceptibility to SLE, while DRB1*15/16 was associated with the presence of oral ulcers in patients with SLE. The haplotype DRB1*13/14.DRB3*01/03 was also more frequent in SLE patients. No other significant associations were found. CONCLUSION: The SLE HLA associations in Jamaicans differ from those in other black populations.....