View
Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Lee, Michael G.
Author Affiliation, Ana.
Department of Medicine
Article Title
Helicobacter pylori - Aspects of the Epidemiology in Jamaica
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
West Indian Medical Journal
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2005
Volume ID
54
Issue ID
2
Page(s)
158-159
Language
n/a
Connective Phrase
n/a
Location/URL
n/a
ISSN
0043-3144 WIMJAD
Notes
n/a
Abstract
Helicobacter pylori infection is one of the commonest chronic infections worldwide. It is estimated that about 30% of the population in developed countries and over 60% in developing countries are infected. In developing countries, infection commonly occurs during childhood. In contrast, in developed countries, infection tends to occur in adult life. An increase in prevalence occurs with age. In Jamaica, an endoscopic study revealed H pylori infection in 55% of 102 patients using gastric biopsy and the urease test for confirmation. In a subsequent endoscopic study, 60% had active infection, by direct testing on gastric biopsy, but 70% had positive serology which indicated previous exposure to H pylori. In an urban community in Kingston, 69% of 202 randomly chosen persons had positive serology for H pylori. In this study, 27% of children under five years of age and 93% of adults 45 years of age and over, had infection. Several factors were associated with infection including: older age, large yard size and the presence of domestic animals in the home environment. Specific virulence associated with H pylori genotypes may influence the development of clinical disease. In Jamaica, of 15 isolates of H pylori in symptomatic patients, 80% were cag A positive and all were genotype Vac A-ml strains with 80% having s lb genotype. The predominant genotype in symptomatic patients in Jamaica is therefore; cag+ vacA s lb-ml, iceA2. (AU)....
read more