Arscott, Guyan; Gabay, L.; Craig, H. R.
Author Affiliation, Ana.
Department of Surgery, Radiology, Anaesthesia ans Intensive Care
Failure of Bromocriptine Therapy to Control Juvenile Mammary Hypertrophy [Abstract]
West Indian Medical Journal
Date of Publication
Introduction: Juvenile mammary hypertrophy is an uncommon syndrome characterized by exaggerated growth at the time of puberty. Attempts to control rapid breast growth using endocrine therapy have generally been met with mixed results. We report a case of juvenile mammary hypertrophy in early adolescence unsuccessfully treated with the anti-prolactin agent bromocriptine. Conclusion: Juvenile mammary hypertrophy occurs in all racial and ethnic groups and has no predisposing factors. Growth is benign and is associated with no other abnormalities. Aetiology is thought to be due to exagerated breast tissue response to normal changes in circulating hormones during puberty. Prolactin is essential for pubertal breast growth; responses to bromocriptine failed to slow the rate of breast enlargement in our patient. The aetiology of her hyperprolactinaemia is uncertain but is unlikely to have contributed to her breast hypertrophy.....