Castle, P. E.; Escoffery, Carlos T.; Schachler, J.; Rattray, Carole A.; Schiffman, M.; Moncada, J.; Sugai, K.; Brown, Claudette; Cranston, Beverley ; Hanchard, Barrie; Palefsky, J. M.; Burk, R. D.; Hutchinson, M. L.; Strickler, H. D.
Author Affiliation, Ana.
Department of Pathology
Chlamydia Trachpmatis, Herpes Simplex Virus 2 and Human T-Cell lymphotropic Virus Type I are not Associated with Grade of Cervical Neoplasia in Jamaica Colposcopy Patients.
Sexually Transmitted Diseases
Date of Publication
Background: Recent studies have suggested that other sexually transmitted infections may increase the likelihood of a human papillomavirus (HPV) infection progressing to high-grade cervical neoplasia and cancer. GOAL: The goal was to assess whether exposures to Chlamydia trachomatis, human T-cell lymphotrophic virus type 1 (HTLV-I), and/or human simplex virus type 2 (HSV-2) are greater in colposcopy patients with cervical intraepithelial neoplasia grade 3 or cancer (CIN3+) than in patients with low-grade cervical neoplasia (CIN1). Study Design: Sequential patients (n=447) attending a colposcopy clinic in Kingston, Jamaica, a country with high cervical cancer rates and high HTLV-I prevalence, were tested for (1) HPV DNA by L1 consensus primer (MY09/11) polymerase chain reaction assays, (2) C trachomatis DNA by ligase chain reaction, (3) C trachomatis antibodies by both microimmunofluorescence and a peptide (VS4) enzyme linked immunosorbent assay (ELISA), (4) HTLV-I antibodies by ELISA confirmed by western blotting, and (5) HSV-2 antibodies by a recombinant HSV-2-specific ELISA. Odds ratios and 95% confidence intervals were estimated with use of multinomial logistic regression models. Results: HPV DNA detection was associated with grade of cervical neoplasia but other evaluated sexually transmitted infections were not. Conclusions: HTLV-I, C trachomatis, and/or HSV-2 were not associated with severity of cervical neoplasia in Jamaican women.....