Author Affiliation, Ana.
Department of Pathology
Human T-Cell Lymphotropic Virus Type 1 (HTLV-I): The Forgotten Retrovirus?
Postgraduate Doctor Caribbean
Date of Publication
Human T-cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus to be isolated and the first to be associated with malignancy. Although there are several million carriers worldwide, only 2-10% develop asscociated disease in their lifetime. The popularity in the early 1980s of HTLV-1 as a model for human retroviral disease has since diminished greatly in the face of the HIV/AIDS global pandemic, generating speculation as to whether HTLV-1 is the 'forgotten' retrovirus. However, in countries where it is endemic, HTLV-1 contributes significantly to morbidity and mortality, and lessons learned from HTLV-1 continue to be relevant to the understanding of human retroviral diseases in general.....