Bazuaye, P.E.; Fletcher, Horace M.; Smikle, Monica ; Jackson, Maria D.; McFarlane-Anderson, Norma
Author Affiliation, Ana.
Department of Basic Medical Sciences
Class 1 HLA-A-B Haplotypes and Tumour Necrosis Factor (TNF-a) - 308 Polymorphism and Cervical dysplasia [Abstract]
West Indian Medical Journal
Date of Publication
54 Suppl. 2
Objective: To determine whether class 1 HLA-A, -B and TNF-a genetic variants are associated with cervical dysplasia. Methods: Subjects were genotyped for (1) HLA class 1 A & B (CIN III and cancer = 68, controls = 88) and (2) TNF-a (CIN I, II, III, cancer = 240, controls = 102). Conclusions: TNF-à SNP-308 inthis population is associated with cervical dysplasia independent of the Class I-A-B MHC genes/haplotypes.....