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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
VanVeldhuisen, Paul C. ; Walters, Michael ; Sawada, Takashi ; Levine, Paul H. ; Wilks, Rainford J. ; Hanchard, Barrie ; Hisada, Michie
Author Affiliation, Ana.
Department of Pathology; Tropical Medicine Research Institute
Article Title
Seroincidence of human T-lymphotropic virus type I infection and characterization of seroconverters in Jamaican food handlers
Medium Designator
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Connective Phrase
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Journal Title
Journal of Acquired Immune Deficiency Syndrome
Translated Title
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Reprint Status
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Date of Publication
2003
Volume ID
33
Issue ID
3
Page(s)
387-392
Language
English
Connective Phrase
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Location/URL
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ISSN
1525-4135
Notes
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Abstract
In a prospective study of food handlers in Jamaica, the authors estimated the age- and sex-specific seroincidence of human T-lymphotropic virus type I (HTLV-I) infection. Of 682 sexually active adults (132 males and 550 females) who were initially seronegative, 12 (1 male and 11 females) seroconverted over 8 years of follow-up. The seroincidence was 1.2 per 1,000 person-years for males and 3.2 per 1,000 person-years for females. The age-standardized incidence was 1.8 times higher for females than for males (P = 0.55). Within a median of 4 years after seroconversion, the median HTLV-I provirus load was 500 copies/105 cells, and the median antibody titer was 1:3109. Four of 12 seroconverters developed antibody to the Tax regulatory protein. HTLV-I infection in this population occurred at a rate comparable with that described for a Japanese cohort. Provirus load, titer and appearance of antibody to the Tax regulatory protein were typical of chronic carriers within a few years of seroconversion.....
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