View
Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Massardo, Domenica Rita; Del Giudice, Luigi; Wolf, Klaus W.
Author Affiliation, Ana.
Electron Microscopy Unit
Article Title
Isolation and characterisation of nuclear mutants with enhanced mitochondrial mutability in the fission yeast Schizosaccharomyces pombe
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Microbiological research
Translated Title
n/a
Reprint Status
n/a
Date of Publication
2002
Volume ID
157
Issue ID
3
Page(s)
197-200
Language
n/a
Connective Phrase
n/a
Location/URL
n/a
ISSN
n/a
Notes
n/a
Abstract
The authors report the isolation and preliminary characterisation of nuclear mutants with increased mitochondrial mutability in fission yeast. Screening of about 2000 clones after nitrosoguanidine mutagenesis led to the isolation of ten mutator mutants. For one of them (mut-1), they show that the mutation is chromosomally encoded. The activity of the mutator is restricted to the mitochondrial genome, since it increases the mutation rate to mitochondrially encoded drug resistance considerably, whereas the mutability of nuclear genes is not altered.....
read more