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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
McKenzie, Colin A.; Sinsheimer, Janet S.; Adeyemo, Adebowale A.; Cox, Roger D.; Southam, Lorraine; Hugill, Alison; Bouzekri, Nourdine; Lathrop, Mark; Forrester, Terrence E.; Cooper, Richard S.; Ward, Ryk
Author Affiliation, Ana.
Tropical Medicine Research Institute
Article Title
SNP Haplotypes in the Angiotensin I-Converting Enzyme (ACE) Gene: Analysis of Nigerian Family Data Using Gamete Competition Models
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Annals of Human Genetics
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2005
Volume ID
69
Issue ID
2
Page(s)
227-232
Language
n/a
Connective Phrase
n/a
Location/URL
n/a
ISSN
n/a
Notes
n/a
Abstract
Gamete competition models were used to explore the relationships between 13 ACE gene polymorphisms and plasma ACE concentration in a set of Nigerian families. Several markers in the 5 and 3 regions of the gene were significantly associated with ACE concentration (P < 10 UTR and the 3 region of the gene were also analysed; in addition to G2350A, in the 3 region, two markers from the 5 UTR (A-5466C and A-240T) were found to be associated with ACE concentration. These results are consistent with reports that have suggested the presence of at least two ACE-linked QTLs, and demonstrate the utility of gamete competition models in the exploratory investigation of the relationship between a quantitative trait and multiple variants in a small genomic region.....
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