View
Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Murphy, Joseph L. ; Badaloo, Asha V.; Chambers, B. ; Forrester, Terrence. E. ; Wootton, S. A. ; Jackson, Alan A.
Author Affiliation, Ana.
Tropical Medicine Research Institute
Article Title
Maldigestion and malabsorption of dietary lipid during severe childhood malnutrition
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Archives of Diseases in Childhood
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2002
Volume ID
87
Issue ID
6
Page(s)
522-525
Language
English
Connective Phrase
n/a
Location/URL
http:; adc.bmjjournals.com/cgi/reprint/87/6/522
ISSN
1468-2044
Notes
n/a
Abstract
Background: Diets rich in lipid are used to provide energy density in treating children with severe malnutrition, but the extent to which their digestion and absorption can cope with the load effectively is uncertain. Aim: To determine the extent of impaired digestion or absorption, in three groups of eight malnourished children (aged 5-23 months) using isotopic probes of the predominant fatty acids in coconut and corn oil used to fortify the diet. Methods: Each child received oral doses of one of three (13)C labelled triglycerides (trilaurin, triolein, or trilinolein). The recovery of (13)C label in stool either as triglyceride (TAG) or fatty acid (FA), was used to assess digestion and absorption. In a separate test, the recovery of label in stool following an oral dose of [(13)C]-glycocholate was measured to assess bile salt malabsorption. Results: The median recovery of label in stool was 9% (range 1-29%) of administered dose. Following treatment there was a reduction in stool (13)C excretion for the labelled TAG (<1%). In half the subjects, label was recovered as TAG in stool (median 0.6%, range 0-44%). Most label in stool was recovered as FA (median 30%, range 0-100%). Following [(13)C]-glycocholate, label was recovered in excess in about one third of studies. Conclusion: Abnormalities in the gastrointestinal handling of lipid were observed in over 50% of children with severe malnutrition, reflecting problems in absorption, although impaired solubilisation or hydrolysis could also be contributory factors. The underlying lesion improves as treatment progresses, leading to concomitant improvement in function.....
read more