Knight-Madden, Jennifer M.
Author Affiliation, Ana.
Tropical Medicine Research Institute
Acute chest syndrome in sickle cell disease
Postgraduate doctor Caribbean
Date of Publication
Sickle cell disease (SCD) is prevalent in many countries. The acute chest syndrome (ACS) is the single most common cause of premature death in persons with SCD, and recurrent ACS is the major predictor of subsequent chronic sickle cell lung disease (SCLD). ACS is characterised by respiratory symptoms and/or signs, with a new infiltrate on chest radiograph. One of several causes of ACS is infection, in which case the condition may require special management because of the immune deficiency associated with SCD. Oxygen, antibiotics, transfusion and physiotherapy are the mainstay of treatment.....