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Publication Type
Conference Proceedings
Author, Analytic
Creary, L.; McKenzie, Colin A.; Hanchard, Neil A.; Taylor, V.; Hambleton, Ian R.; Forrester, Terrence E.; Thein S.
Author Role
Presenters
Author Affiliation
Tropical Medicine Research Institute
Paper/Section Title
Differences in fetal haemoglobin and F cell levels in adults: data from Afro-Caribbean, European and Afro-German subjects
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Proceedings Title
Fiftieth Annual Scientific Meeting of the Caribbean Health Research Council
Date of Meeting
April 21-23, 2005
Place of Meeting
Trinidad and Tobago
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Abstract
Objective: To measure and compare levels of fetal haemoglobin (HbF) and erythrocytes containing HbF (F cells, FC) in healthy subjects from different ethnic groups, in order to assess the feasibility of mapping genes for these traits in subjects of admixed ethnicity. Design and Methods: Afro-Caribbean adults (aged 18 years and over) were recruited from among blood donors in Kingston, Jamaica. White Europeans were expatriates living and working in Kingston and Spanish Town, Jamaica. Afro-German adults were recruited from a German enclave community in rural Jamaica. HbF levels were determined by the alkaline denaturation test. FC levels were determined by fluorescence-activated cell sorting of peripheral blood reacted with a mouse monoclonal anti-ăglobin chain antibody Results: Data from 150 Afro-Caribbean, 44 European and 73 Afro-German HbAA subjects were available for analysis. In all three ethnic groups, the distribution of HbF and FC was continuous and positively skewed. The majority (~90%) of subjects in each group had FC levels of approximately 4% and HbF less than 1%. The median HbF and FC levels were 0.52% (IQR 0.42) and 3.51% (IQR 3.51) respectively in the Afro-Caribbean sample; 0.48% (IQR 0.51) and 2.85% (IQR 2.05) respectively in the European sample; 0.55% (IQR 0.41) and 3.20% (IQR 2.61) respectively in the Afro-German sample. There were no significant differences in HbF and FC levels between the three groups (HbF; ÷2 = 0.61, P = 0.74 and FC; ÷2 = 5.42, P = 0.07). Conclusions: These preliminary results suggest that ethnic differences in levels of HbF and FC are unlikely to be large. Further studies are required to confirm these findings.....
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