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Publication Type
Journal Article
Author, Analytic
Tulloch-Reid, Marshall K. ; Hanson, Robert L. ; Saremi, Aramesh; Looker, Helen C. ; Williams, Desmond E. ; Krakoff, J. ; Knowler, William C.
Author Affiliation, Ana.
Tropical Medicine Research Institute
Article Title
Hematocrit and the incidence of type 2 diabetes in the Pima Indians
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Diabetes Care
Translated Title
n/a
Reprint Status
n/a
Date of Publication
2004
Volume ID
27
Issue ID
9
Page(s)
2245-2246
Language
English
Connective Phrase
n/a
Location/URL
http:; care.diabetesjournals.org/cgi/reprint/27/9/2245
ISSN
0149-5992
Notes
n/a
Abstract
Several prospective studies have shown that a high hematocrit (or hemoglobin) predicts type 2 diabetes. However, the reasons for this association have not been fully explored. Hematocrit has been positively correlated with hyperinsulinemia and conditions associated with insulin resistance such as high blood pressure, elevated serum triglycerides, low HDL cholesterol, and central obesity and could, therefore, be associated with insulin resistance. On the other hand, hematocrit is also a major determinant of blood viscosity. An elevated blood viscosity is thought to contribute to the development of insulin resistance by reducing blood flow to skeletal muscle, thereby interfering with insulin-mediated glucose uptake in this tissue.The aim of this study was to examine the association between hematocrit and type 2 diabetes incidence in the Pima Indians and to determine whether any association between hematocrit and diabetes incidence was altered by adjustment for fasting insulin.....
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