Ragoobirsingh, Dalip; Robinson, Hazel M; Morrison, Errol Y
Author Affiliation, Ana.
Basic Medical Sciences (Anatomy, Biochemistry, Physiology)
Effects of cassava cyanoglucoside, linamarin, on blood sugar levels in the dog.
Journal of Nutrition and Biochemistry
Date of Publication
The study examines the diabetogenicity of linamarin in dogs of different nutritional status. The total dog population was 35; 15 normal, 10 undernourished, and 10 recovered. The recovered dogs were the refed undernourished dogs, Fasting plasma insulin and insulin receptor studies, followed by a controlled glucose tolerance test, were done on each dog. After the dogs were fed linamarin. 0.5 hour was allowed to elapse before these investigations were repeated. In the linamarin-treated undernourished animals, plasma insulin and insulin binding to erythrocytes and mononuclear leucocytes were significantly (p<0.01) lower than in the control animals, and this resulted in abnormally high glucose levels. Linamarin administration had no effect on plasma insulin, insulin binding, or blood sugar levels in the normal and recovered dogs. These results point to the possible aetiology of diabetes in the undernourished state by 'toxic' food substances such as linamarin.....