View
Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Alexander-Lindo, R. L. ; Morrison, E. Y. ; Nair, M. G
Author Affiliation, Ana.
Department of Basic Medical Sciences
Article Title
Hypoglycaemic effect of stigmast-4-en-3-one and its corresponding alcohol from the bark of Anacardium occidentale (cashew)
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Phytotheraphy Research
Translated Title
n/a
Reprint Status
n/a
Date of Publication
2004
Volume ID
18
Issue ID
5
Page(s)
403-7
Language
eng
Connective Phrase
n/a
Location/URL
n/a
ISSN
0951-418X (Print)
Notes
n/a
Abstract
Intravenous administration of the hexane extract of the bark of Anacardium occidentale (cashew) in normal, healthy dogs produced a significant lowering of the blood glucose levels. Pursuit of the hypoglycaemic principle(s) in the hexane extract resulted in the isolation and characterization of two compounds, stigmast-4-en-3-ol (1) and stigmast-4-en-3-one (2). These compounds were purified by chromatographic methods and the structures were characterized by spectroscopic methods. Both compounds produced significant hypoglycaemic activity after intravenous administration at a dose of 1.3 mg/kg body weight. The bark of the cashew plant, A. occidentale, exhibited a hypoglycaemic effect probably due to the presence of these compounds.....
read more