Williams, L.A.D.; Fletcher, Cyril K.; Gardner, Michael; Singh, P.D. A.; Choo-Kang, Eric G.; Rickards, E.
Author Affiliation, Ana.
Basic Medical Sciences (Anatomy, Biochemistry, Physiology); Faculty of Medical Sciences
Toxic effects of a non-polar extract of the leaves of Artocarpus altilis (Park. ) following sub-acute administration to rats
Philippine Journal of Science
Date of Publication
Intraperitoneal injection of hexane soluble compounds from the leaves of Artocarpus altilis lowered the following haematological parameters in rats: white blood cell counts, thrombocytes and haemoglobin. Plasma analysis also revealed a significant lowering of total bilirubin, aspartate aminotransferase and alkaline phosphatase. Histological examination of the liver, kidney and lung revealed extensive erythrocytic aggregation. Prominent peribronchial and perivascular lymphatic hyperplasia in the lungs, and marked follicular hyperplasia in the spleen were seen....