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Publication Type
Journal Article
Author, Analytic
Brown, E. E. ; Brown, B. J. ; Yeager, M. ; Welch, R. ; Cranston, B. ; Hanchard, Barrie ; Hisada, M.
Author Affiliation, Ana.
n/a
Article Title
Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among children
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Journal of Infect Diseases
Translated Title
n/a
Reprint Status
n/a
Date of Publication
2006
Volume ID
194
Issue ID
11
Page(s)
1565-9
Language
eng
Connective Phrase
n/a
Location/URL
n/a
ISSN
0022-1899 (Print)
Notes
n/a
Abstract
To characterize a host polygenic profile associated with susceptibility to human T lymphotropic virus type I (HTLV-I) infection, we examined common variants in 11 immune-related genes among Jamaican children born to HTLV-I-seropositive mothers. Compared with HTLV-I seronegatives, haplotypes of IL6 (-660G/-635C/-236G) and IL10 (-6653C/-1116G) were significantly associated with HTLV-I infection in children independent of maternal provirus load and duration of breast-feeding (odds ratio [OR], 4.5 [95% confidence interval {CI}, 1.2-17.6], and OR, 3.5 [95% CI, 1.4-9.0], respectively). Our findings are the first, to our knowledge, to suggest that host variation in both proinflammatory and anti-inflammatory genes could influence susceptibility to HTLV-I infection.....
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