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Publication Type
Journal Article
Author, Analytic
Biggar, R. J. ; Ng, J. ; Kim, N. ; Hisada, M. ; Li, H. C. ; Cranston, B. ; Hanchard, Barrie ; Maloney, E. M.
Author Affiliation, Ana.
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Article Title
Human leukocyte antigen concordance and the transmission risk via breast-feeding of human T cell lymphotropic virus type I
Medium Designator
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Connective Phrase
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Journal Title
Journal of Infect Diseases
Translated Title
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Reprint Status
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Date of Publication
2006
Volume ID
193
Issue ID
2
Page(s)
277-82
Language
eng
Connective Phrase
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Location/URL
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ISSN
0022-1899 (Print)
Notes
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Abstract
OBJECTIVE: We examined the association between mother-to-child human T cell lymphotropic virus type I (HTLV-I) transmission and human leukocyte antigen (HLA) class I types. METHODS: In 1989, children born to HTLV-I-infected mothers in Jamaica were enrolled and prospectively evaluated for HTLV-I infection. HLA class I types in mothers and children were determined by DNA-based polymerase chain reaction methods. Associations between HLA class I types and transmission of HTLV-I were analyzed using proportional-hazards regression models adjusted for the duration of breast-feeding. Transmission risk in children still breast-feeding at 12 months was determined using actuarial methods. RESULTS: Of 162 children, 28 (17%) became infected. After Bonferroni's adjustment for multiple comparisons, the transmission risk was not influenced by any specific HLA class type or the A2 supertype. However, compared with children who shared 3 HLA class I types with their mothers (the minimum number possible), the transmission risk increased 1.8-fold with 4 shared types and 3.0-fold with 5 or 6 shared types (Ptrend = .039; 1.75-fold increase for each additional concordant HLA type). This association was independent of maternal HTLV-I proviral level, antibody titer, and household income. CONCLUSIONS: We found a significant dose-response relationship between HTLV-I transmission via breast-feeding and mother-child HLA class I type concordance. Immunological interactions between a child's cells and maternal cells may influence the risk of HTLV-I infection by breast-feeding, perhaps because antigens on maternal cells are seen by the child as being 'self.'....
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