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Publication Type
Journal Article
Author, Analytic
Boyne, M. S. ; Sargeant, L. A. ; Bennett, F. I. ; Wilks, Rainford J. ; Cooper, R. S. ; Forrester, T. E.
Author Affiliation, Ana.
n/a
Article Title
Isoprostanes, a marker of lipid peroxidation, may not be involved in the development of glucose intolerance
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Diabetes Res Clin Pract
Translated Title
n/a
Reprint Status
n/a
Date of Publication
2007
Volume ID
76
Issue ID
1
Page(s)
149-51
Language
eng
Connective Phrase
n/a
Location/URL
n/a
ISSN
0168-8227 (Print)
Notes
n/a
Abstract
We investigated whether isoprostanes, as a marker of lipid peroxidation, may be involved in the development of impaired glucose tolerance (IGT) or diabetes. Using a nested case-control study, we tracked the changes in isoprostane levels, insulin sensitivity (IS) and beta-cell function (BCF) in Afro-Jamaicans who progressed to IGT and diabetes over 3.9 years. Anthropometry, glucose tolerance, insulin levels, blood pressure and urinary isoprostane concentration were measured at baseline and follow-up. IS and BCF were estimated by the method of homeostasis assessment. Fifty-two individuals who progressed to IGT or diabetes and 44 age, sex and body mass index (BMI) matched controls were studied. Progression to glucose intolerance was significantly related with baseline BCF (p0.1). We concluded that isoprostanes may not be causally involved in the development of glucose intolerance, insulin resistance or deteriorating BCF.....
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