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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Chen, Avril R. ; Ruddock, P.L.D. ; Lamm, A.S. ; Reynolds, W.F. ; Reese, Paul B
Author Affiliation, Ana.
Department of Chemistry
Article Title
Stemodane and stemarane diterpenoid hydroxylation by Mucor plumbers and Whetzelina sclerotiorum
Medium Designator
n/a
Connective Phrase
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Journal Title
Phytochemistry
Translated Title
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Reprint Status
n/a
Date of Publication
2005
Volume ID
66
Issue ID
16
Page(s)
1898-1902
Language
n/a
Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Incubation of stemodin (1) with Mucor plumbeus ATCC 4740 resulted in the formation of 2a,6,13-trihydroxystemodane (2), 2a,3,13-trihydroxystemodane (3), 2a,11,13-trihydroxystemodane (4) and 2a,13,14-trihydroxystemodane (5), while stemodinone (7) afforded 6a,13-dihydroxystemodan-2-one (8) and 6a,12a,13-trihydroxystemodan-2-one (9). Metabolites obtained from the bioconversion of stemarin (11) were 8,13,19-trihydroxystemarane (12) and 2a,13,19-trihydroxystemarane (13). 19-N,N-Dimethylcarbamoxy-13-hydroxystemarane (14) was not transformed by the fungus. Stemodin (1) was incubated with Whetzelinia sclerotiorum ATCC 18687 to produce 2a,7,13-trihydroxystemodane (6) and 2a,11,13-trihydroxystemodane (4). Stemodinone (7) was converted to 7,13-dihydroxystemodan-2-one (10). Compounds 2, 4, 9, 10, 12 and 13 have not been previously reported....
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