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Publication Type
Journal Article
Author, Analytic
Gossell-Williams, Maxine D.; Fletcher, Horace; McFarlane-Anderson, Norma; Jacob, A.; Patel, J.; Zeisel, S.H
Author Affiliation, Ana.
Department of Basic Medical Sciences; Department of Obstetrics, Gynaecology and Child Health
Article Title
Dietary intake of choline and plasma choline concentrations in pregnant women in Jamaica
Medium Designator
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Connective Phrase
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Journal Title
West Indian Medical Journal
Translated Title
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Reprint Status
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Date of Publication
2005
Volume ID
54
Issue ID
6
Page(s)
355-359
Language
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Connective Phrase
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Location/URL
http:; caribbean.scielo.org/pdf/wimj/v54n6/v54n6a02.pdf
ISSN
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Notes
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Abstract
Choline is an essential nutrient for humans and its availability during pregnancy is important for optimal fetal development. The Food and Nutrition Board of the Institute of Medicine in the United States of America has set the adequate choline intake during pregnancy at 450 mg/day. There is limited data available on normal plasma choline concentrations in pregnancy. Moreover, there are neither documented studies of choline intake among pregnant women in the Jamaican population nor of free plasma choline concentrations during pregnancy. Sixteen women presenting to the antenatal clinic of the University Hospital of the West Indies (UHWI) at 10-15 weeks of gestation were selected for this pilot study. A food frequency questionnaire was administered to estimate frequency of consumption of foods rich in choline. Fasting blood samples were collected by venepuncture and plasma assayed for choline using liquid chromatography electrospray ionization isotopic dilution mass spectrometry. Most of the women reported consumption of diets that delivered less than the recommended choline intake (mean +/- SEM, 278.5 +/- 28.9 mg). Mean plasma choline concentration was 8.4 +/- 0.4 micromol/L. This falls below the normal concentration (10 micromol/L) reported for individuals that are not pregnant and pregnant (14.5 micromol/L). The results of this study may be an indication that the choline included in the diet of pregnant women in Jamaica may not be adequate to meet both the needs of the mother and fetus and that further studies are warranted to determine clinical implications....
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