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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Williams, L. A. ; Conrad, J. ; Vogler, B. ; Rosner, H. ; Porter, R. B. ; Setzer, W. ; Barton, E. N. ; Levy, H. G. ; Mika, S. ; Klaiber, I. ; Nkurunziza, J. P. ; Kraus, W.
Author Affiliation, Ana.
n/a
Article Title
In vitro anti-proliferation/cytotoxic activity of epingaione and its derivatives on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
West Indian Medical Journal
Translated Title
n/a
Reprint Status
n/a
Date of Publication
2007
Volume ID
56
Issue ID
1
Page(s)
5-10
Language
eng
Connective Phrase
n/a
Location/URL
http:; caribbean.scielo.org/pdf/wimj/v56n1/a02v56n1.pdf
ISSN
0043-3144 (Print)
Notes
n/a
Abstract
Epingaione (4-Methyl-1-(5-methyl-2, 3,4,5-tetrahydro-[2,3']bifuranyl-5-yl)-pentan-2-one) was isolated as one of the major lipophilic secondary metabolites from the leaves and stems of Bontia daphnoides L. The compound gave 79.24% and 50.83% anti-proliferation/cytotoxic activity on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells in vitro at 50 pg/mL, respectively. Epingaione was transformed into eleven derivatives under laboratory conditions using ethanol, some gave greater anti-proliferation/cytotoxic activity on the cancer cell lines tested. One of the derivatives (compound 2) with enhanced cytotoxic activity was elucidated as 5'-Ethoxy-5-methyl-5-(4-methyl-2-oxo-pentyl)-2,3,4,5-tetrahydro-5'H-[2,3'] bifuranyl-2'-one. Both epingaione and compound 2 caused an accumulation of arrested or dead SH-SY5Y neuroblastoma in the m-phase of the cell cycle as revealed by the m-phase specific marker KE 67.....
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