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Publication Type
Journal Article
Author, Analytic
Badaloo, A. V. ; Forrester, T. ; Reid, M. ; Jahoor, F.
Author Affiliation, Ana.
Tropical Medicine Research Institute
Article Title
Lipid kinetic differences between children with kwashiorkor and those with marasmus
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Am J Clin Nutr
Translated Title
n/a
Reprint Status
n/a
Date of Publication
2006
Volume ID
83
Issue ID
6
Page(s)
1283-8
Language
eng
Connective Phrase
n/a
Location/URL
n/a
ISSN
0002-9165 (Print)
Notes
Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica. asha.baldaloo@uwimona.edu.jm
Abstract
BACKGROUND: It has been hypothesized that one factor associated with poor prognosis in kwashiorkor, but not in marasmus, is impaired lipid catabolism, which limits the supply of energy that is essential for survival when dietary intake is inadequate. However, this hypothesis has not been tested. OBJECTIVE: The objective was to measure lipid kinetics in malnourished children with kwashiorkor or marasmus. DESIGN: Glycerol concentration and flux (index of total lipolysis), palmitate concentration and flux (index of net lipolysis), and palmitate oxidation rate (index of fatty acid oxidation) were measured in 8 children (n = 5 boys and 3 girls) with kwashiorkor and 7 (n = 4 boys and 3 girls) with marasmus, aged 4-20 mo, in the postabsorptive state. The measurements were made approximately 3 d after admission, when the children were malnourished, and after the children attained normal weight-for-length, ie, at recovery. RESULTS: The glycerol concentration was higher in the malnourished stage than at recovery for the marasmus and kwashiorkor groups combined. Glycerol flux tended to be lower (P = 0.067) and palmitate flux significantly lower (P < 0.05) in the kwashiorkor group than in the marasmus group. Palmitate oxidation was significantly lower in the malnourished stage than at recovery in the kwashiorkor group but not in the marasmus group. In the malnourished stage, palmitate oxidation was slower in the kwashiorkor group than in the marasmus group, but no significant differences between groups were observed at recovery. CONCLUSIONS: Children with kwashiorkor break down fat and oxidize fatty acids less efficiently than do children with marasmus; this factor may explain the better survival rate in marasmus.....
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