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Publication Type
Conference Proceedings
Author, Analytic
McGrowder, Donovan; Ragoobirsingh, Dalip; Dasgupta, Tara
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Paper/Section Title
Search for new nitric oxide releasing drugs which are useful in the treatment of hypertension and their possible involvement in the aetiology of non-insulin-dependent diabetes mellitus
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Proceedings Title
Annual National Conference on Science and Technology: Science and Technology for Economic Growth and Development: Proceedings of the Seventeenth Annual National Conference on Science and Technology
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Place of Meeting
Kingston, Jamaica
Place of Publication
Kingston, Jamaica
Publisher Name
The Scientific Research Council
Date of Publication
2003
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Abstract
Diabetes and hypertension increase the risk of premature mortality and contribute to several causes of death leading to heart disease and stroke in the Jamaican population. There is a recent reported 17.9% prevalence of diabetes in Jamaica. Preeclampsia is a hypertensive disorder specific to pregnancy. The incidence in Jamaica is 4.1%. S-nitrosoglutathione (GSNO), a nitric oxide (NO) donor has been used to prevent platelet activation in patients with preeclampsia and those undergoing percutaneous transluminal coronary angioplasty. The study investigated the pharmacological effect of GSNO on glucose metabolism in an animal model. The results indicate that GSNO decreased mean artrial blood pressure and increased postprandial blood glucose levels due to impaired insulin release. The decreased binding of insulin to its receptor on the cell membranes of erythrocytes and mononuclear leucocytes was attributed to decreased insulin receptor sites and receptor affinity. The clinical relevance of the study is that GSNO treatment although beneficial, can cause hyperglycaemia which may be a side effect in patients with the above mentioned hypertensive disorders. These findings suggest the first evidence of the involvement of NO in the aetiology of non-insulin-dependent diabetes mellitus and illustrate the putative primary molecular defect observed in the “pre-diabetic”state.....
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