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Publication Type
Conference Proceedings
UWI Author(s)
Author, Analytic
McAnuff, Marie A.; Omoruyi, Felix O.; Morrison, Errol Y.; Asemota, Helen N.
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Paper/Section Title
Science and technology for economic development: Technology driven agriculture and agro-processing
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Proceedings Title
Annual National Conference on Science and Technology: Science and Technology for Economic Growth and Development: Proceedings of the Seventeenth Annual National Conference on Science and Technology
Date of Meeting
November 19-22, 2003
Place of Meeting
Kingston, Jamaica
Place of Publication
Kingston, Jamaica
Publisher Name
The Scientific Research Council
Date of Publication
2003
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Abstract
To investigate the effect of yam steroidal sapogenin extract on lipid peroxidation in streptozotocin-induced diabetic rats. Diabetic male wistar rats (n=32) were fed diets supplemented with 1% bitter yam steroidal sapogenin extract or commercial diosgenin for three weeks. Thiobarbituric acid reactive substances (TBARS), conjugated dienes, lipid profile and the activities of alanine and aspartate transaminases and acid phosphatase were measured in the liver. The diabetic rats (fed normal, sapogenin extract from Jamaican wild yam and commercial diosgenin diets respectively) lost weight significantly (P<0.05) compared to the normal group even though there was no significant difference (P<0.05) in their feed intake. There was no significant change (P<0.05) in liver weight. Total cholesterol and VLDL-cholesterol decreased significantly (P<0.05), while HDL-cholesterol levels increased significantly in rats fed diets supplemented with commercial diosgenin and wild yam sapogenin extract compared to diabetic control. There was no significant change in phospholipids and triglyceride levels. The feeding of commercial diosgenin and wild yam sapogenin extract resulted in a significant decrease in conjugated dienes and thiobarbituric acid reactive substances (TBARS) compared to the unsupplemented diabetic groups and normal rats. Yam extract and commercial diosgenin also caused a significant decrease in the diabetes!-induced increase in alanine transaminase activity. However, they had no effect on aspartate and acid phosphatase levels. Results obtained suggests that the feeding of bitter yam steroidal sapogenin extract to diabetic rats may result in alterations in the lipid composition of liver with subsequent reduction in lipid peroxidation. Data from this study also shows that the consumption of sapogenin extract from wild yam decreased liver damage associated with diabetes.....
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