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Publication Type
Journal Article
Author, Analytic
Williams, L.A.D.; Singh, P.D.A.; Caleb-Williams, L.S.
Author Affiliation, Ana.
Basic Medical Sciences (Anatomy, Biochemistry, Physiology); Faculty of Medical Sciences
Article Title
Biology and biological action of the defensive secretion from a Jamaican millipede
Medium Designator
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Connective Phrase
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Journal Title
Naturwissenschaften
Translated Title
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Reprint Status
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Date of Publication
1997
Volume ID
84
Issue ID
4
Page(s)
143-144
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Analysis of the defensive quinone secretion from the Jamaican millipede, Orthoporus antillanus revealed that it consisted of six benzoquinones. These compounds were toxic to three human pathogenic fungi (Fonsecaea pedrosa, Candida albicans and Micosporum gypseum); a plant fungus (Fusarium oxysporium); a bacterium (Xanthomonas campestris); a soil nematode (Rotylenchus reniformis); and a human parasitic nematode (Strongyloides stercoralis). Using the rat phrenic nerve-hemidiaphragm preparation, the toxicity of the secretion to muscle and nerve was highlighted. The usefulness of these quinones as prototype molecules for the development of antibacterial and antifungal agents is indicated.....
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Keywords
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