Williams, L.A.D.; Singh, P.D.A.; Caleb-Williams, L.S.
Author Affiliation, Ana.
Basic Medical Sciences (Anatomy, Biochemistry, Physiology); Faculty of Medical Sciences
Biology and biological action of the defensive secretion from a Jamaican millipede
Date of Publication
Analysis of the defensive quinone secretion from the Jamaican millipede, Orthoporus antillanus revealed that it consisted of six benzoquinones. These compounds were toxic to three human pathogenic fungi (Fonsecaea pedrosa, Candida albicans and Micosporum gypseum); a plant fungus (Fusarium oxysporium); a bacterium (Xanthomonas campestris); a soil nematode (Rotylenchus reniformis); and a human parasitic nematode (Strongyloides stercoralis). Using the rat phrenic nerve-hemidiaphragm preparation, the toxicity of the secretion to muscle and nerve was highlighted. The usefulness of these quinones as prototype molecules for the development of antibacterial and antifungal agents is indicated.....