View
Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Omoruyi, Felix O.
Author Affiliation, Ana.
n/a
Article Title
Jamaican bitter yam sapogenin: potential mechanisms of action in diabetes
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Plant Foods Hum Nutr
Translated Title
n/a
Reprint Status
n/a
Date of Publication
2008 Sep
Volume ID
63
Issue ID
3
Page(s)
135-40
Language
eng
Connective Phrase
n/a
Location/URL
http:; www.ncbi.nlm.nih.gov/pubmed/18594988
ISSN
0921-9668 (Print)
Notes
n/a
Abstract
Sapogenin has been proposed to be the active component responsible for the beneficial effects of Jamaican bitter yam (Dioscorea polygonoides) in the management of diabetes. Most of the research activities on bitter yam have focused on the role sapogenin play in the management of diabetes. Changes in weight, activities of carbohydrate digestive and transport enzymes, alterations in the intestinal morphology, changes in blood lipids, reduction in lipid peroxidation and the prevention of liver damage associated with diabetes have all been attributed to bitter yam sapogenin supplementation. Also, the possible exploitation of bitter yam for nutraceutical/pharmaceutical purposes is based on the high saponin content. There are however, concerns about the beneficial claims of the findings especially with regard to the possible adverse effects that may accrue in the clinical applications. This review therefore provides an overview of the findings in this research area with a view to proposing the potential mechanisms whereby the supplement of bitter yam sapogenin extract exert its hypoglycemic and hypolipidemic properties and the probable adverse effects in diabetes mellitus.....
read more