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Publication Type
Journal Article
Author, Analytic
Riley, C. K. ; Adebayo, S. A. ; Wheatley, Andrew. O. ; Asemota, Helen. N.
Author Affiliation, Ana.
n/a
Article Title
The interplay between yam (Dioscorea sp.) starch botanical source, micromeritics and functionality in paracetamol granules for reconstitution
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Eur J Pharm Biopharm
Translated Title
n/a
Reprint Status
n/a
Date of Publication
2008 Sep
Volume ID
70
Issue ID
1
Page(s)
326-34
Language
eng
Connective Phrase
n/a
Location/URL
18423995
ISSN
0939-6411 (Print)
Notes
n/a
Abstract
A comparative investigation of the interplay between starch botanical source, micromeritics and their functionality in formulated paediatric paracetamol granules for reconstitution was conducted using starches extracted from five local yam (Dioscorea spp.) species. Significant differences were observed in the physicochemical properties of the different starches studied (p<0.05). The observed differences in paracetamol dissolution correlated well with the physicochemical properties of the starches. Granules formulated with Chinese yam and Bitter yam starches showed the fastest rate of paracetamol dissolution with T(80) of 2.2 and 2.6 min, respectively, at 2.5%w/w, and 3.75 and 4.00 min, respectively, at 10% w/w binder concentrations. Those formulated with Round leaf yellow yam starch had the slowest dissolution rate with T(80) of 4.5 and 8.75 min, respectively, at 2.5% and 10% binder concentrations. The results generally indicate a significant dependence of the rate of paracetamol dissolution from granules on starch surface tension, viscosity, swelling power and water binding capacity, particle size distribution, specific surface and porosity. These, in turn, were found to be starch botanic source-dependent suggesting careful consideration of botanic source when substituting one starch product for another in granule formulation.....
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