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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Goedert, J.J; Li, H.C; Gao, X.J; Chatterjee, N; Sonoda, S; Biggar, R.J; Cranston, B; Kim, N; Carrington, M; Morgan, O; Hanchard, B; Hisada, M
Author Affiliation, Ana.
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Article Title
Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types.
Medium Designator
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Connective Phrase
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Journal Title
International Journal of Cancer
Translated Title
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Reprint Status
Refereed
Date of Publication
2007
Volume ID
121
Issue ID
5
Page(s)
1092-1097
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Human T-lymphotropic virus-I (HTLV-I) causes adult T-cell leukemia/lymphoma (ATL) and HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class-I (A,B) and class-II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM/TSP patients and 190 population-based, asymptomatic HTLV-I-infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence >50% of asymptomatic carriers) and by prevalence quartile. HTLV-I proviral load between asymptomatic carriers with common versus uncommon types was compared by t-test. ATL differed from asymptomatic carriers in overall DQB1 allele and class-I haplotype frequencies (p ....
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Keywords