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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Jackson, S.T.; Mullings, Anthony M.; Booth, T.F.; MacDonald, L.; Henry, S.O.; Khan, C.A.; McLaughlin, P.D.
Author Affiliation, Ana.
n/a
Article Title
Molecular analysis and implications of neurovirulent circulating vaccine-derived poliovirus in Jamaica: A case report and review of literature
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
West Indian Medical Journal
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2008
Volume ID
57
Issue ID
5
Page(s)
511-514
Language
n/a
Connective Phrase
n/a
Location/URL
http:; caribbean.scielo.org/scielo.php?script=sci_arttext&pid=S0043-31442008000500018&lng=en&nrm=.pf
ISSN
n/a
Notes
n/a
Abstract
As the goal to eradicate wild polio virus (WPV) is approached, outbreaks associated with vaccine derived polioviruses (VDPV) with neurovirulent properties have emerged. The relevance for the spread of infection by nonparalytic cVDPV cases, with mutations associated with neurovirulence, is discussed with reference to the molecular analysis of a VDPV isolated from a Jamaican child who presented with aseptic meningitis. Potential risks to the Jamaican community resulting from circulation of cVDPV, and critical factors defined by the World Health Organization (WHO) in the global eradication of Polio are analyzed in the context of immunization coverage, and the need to stop all Oral Polio Vaccine (OPV) use once wild polioviruses (WPVs) have been eradicated.....
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