Smikle, Monica ; Barton, Everard N.; Morgan, Owen St. C.; DeCeulaer, Karel
Author Affiliation, Ana.
Photosensitivity and antinuclear antibodies in black patients with systemic lupus erythematosus.
Journal of the Association of Academic Minorities
Date of Publication
Black patients with systemic lupus erythematosus (SLE) have a lower prevalence of photosensitivity rashes than white patients. The reasons for this are unknown, but some studies suggest a correlation between the presence of antinuclear antibodies and protection from photosensitivity. Serum antinuclear-antibody profiles - including anti-dsDNA, anti-Sm, anti-RNP, anti-Ro/SS-A, anti-La/SS-B antibodies - were determined in 91 black Jamaican patients with SLE. All 91 serum samples from SLE patients were positive in the fluorescent antinuclear-antibody test. Using the Crithidia luciliae immunofluorescence test, anti-dsDNA was found in 27.5 % of the samples. By a double immunodiffusion method, anti-Sm antibodies were found in 15.4%, anti-RNP in 18.7%, anti-Ro/SS-A in 9.9 % and anti-La/SS-B in 11.0%. However, no statistically significant differences were observed in the seroprevalence of these antinuclear antibodies when sera from patients of the following groups were compared: only photosensitivity rashes (n = 17), photosensitivity and other rashes (n = 23), other rashes without photosensitivity (n = 27), and patients with no skin rash of any type (n = 24). These results suggest that photosensitivity in black Jamaican patients with SLE is not associated with antinuclear-antibody specificity.....