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Publication Type
Journal Article
Author, Analytic
Smikle, Monica ; Barton, Everard N.; Morgan, Owen St. C.; DeCeulaer, Karel
Author Affiliation, Ana.
Microbiology; Medicine
Article Title
Photosensitivity and antinuclear antibodies in black patients with systemic lupus erythematosus.
Medium Designator
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Connective Phrase
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Journal Title
Journal of the Association of Academic Minorities
Translated Title
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Reprint Status
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Date of Publication
1996
Volume ID
7
Issue ID
2
Page(s)
53-5
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Black patients with systemic lupus erythematosus (SLE) have a lower prevalence of photosensitivity rashes than white patients. The reasons for this are unknown, but some studies suggest a correlation between the presence of antinuclear antibodies and protection from photosensitivity. Serum antinuclear-antibody profiles - including anti-dsDNA, anti-Sm, anti-RNP, anti-Ro/SS-A, anti-La/SS-B antibodies - were determined in 91 black Jamaican patients with SLE. All 91 serum samples from SLE patients were positive in the fluorescent antinuclear-antibody test. Using the Crithidia luciliae immunofluorescence test, anti-dsDNA was found in 27.5 % of the samples. By a double immunodiffusion method, anti-Sm antibodies were found in 15.4%, anti-RNP in 18.7%, anti-Ro/SS-A in 9.9 % and anti-La/SS-B in 11.0%. However, no statistically significant differences were observed in the seroprevalence of these antinuclear antibodies when sera from patients of the following groups were compared: only photosensitivity rashes (n = 17), photosensitivity and other rashes (n = 23), other rashes without photosensitivity (n = 27), and patients with no skin rash of any type (n = 24). These results suggest that photosensitivity in black Jamaican patients with SLE is not associated with antinuclear-antibody specificity.....
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