Birmann, Brenda M.; Breen, Elizabeth C.; Stuver, Sherri; Cranston, Beverly; Martinez-Maza, Otoniel; Falk, Kerstin l.; Okayama, Akihiko; Hanchard, Barrie; Muellen, Nancy; Hisada, Michie
Author Affiliation, Ana.
Population differences in immune marker profiles associated with human T-Lymphotropic virus Type 1 infection in Japan and Jamaica.
International Journal of Cancer
Date of Publication
The natural history of human T-lymphotropic virus type I (HTLV-I) has been shown to differ markedly by geographic area. The differences include contrasting patterns of risk of adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which may be due in part to differences in host immune response to infection. To characterize variations in host immunity across populations, we compared serologic immune marker patterns in HTLV-I-endemic populations in Japan and Jamaica. We matched 204 participants with archived blood from the Miyazaki Cohort Study (Japan) and the Food Handlers Study (Jamaica)—i.e., 51 HTLV-I-positive (‘‘carriers’’) and 51 HTLV-I-negative individuals (‘‘noncarriers’’) from each population—by age, sex and blood collection year. We compared plasma concentrations of markers of T-cell-mediated (antigen-specific) and nonspecific immunity using regression models and correlation coefficients. Compared to Jamaican HTLV-I noncarriers, Japanese noncarriers had higher covariate-adjusted mean levels of T-cell activation markers, including antibody to Epstein-Barr virus nuclear antigen-1 (reciprocal titer 27 vs. 71, respectively, p 5 0.005), soluble interleukin-2 receptor-a (477 vs. 623 pg/mL, p 5 0.0008) and soluble CD30 (34 vs. 46 U/mL, p 5 0.0001) and lower levels of C-reactive protein (1.1 vs. 0.43 lg/mL, p 5 0.0004). HTLVI infection was associated with activated T-cell immunity in Jamaicans but with diminished T-cell immunity in Japanese persons. The observed population differences in background and HTLV-Irelated host immunity correspond closely to the divergent natural histories of infection observed among HTLV-I carriers in Japan and Jamaica and corroborate a role for host immune status in the contrasting patterns of ATL and HAM/TSP risk.....