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Publication Type
Journal Article
Author, Analytic
Lindo, John F.,; Atkins, Neil S.; Lee, Michael G.; Robinson, Ralph, D.; Bundy, Donald A. P.
Author Affiliation, Ana.
Microbiology; Medicine; Basic Medical Sciences (Anatomy, Biochemistry, Physiology)
Article Title
Short report: Long-term serum antibody isotype responses to Strongyloides stercoralis filariform antigens in eight patients treated with ivermectin.
Medium Designator
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Connective Phrase
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Journal Title
American Journal of Tropical Medicine and Hygiene
Translated Title
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Reprint Status
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Date of Publication
1996
Volume ID
55
Issue ID
5
Page(s)
474-6
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
The enzyme-linked immunosorbant assay was used to investigate long-term changes in serum immunoglobulin G1 (IgG1), IgG4, IgE, and IgA against Strongyloides stercoralis phosphate-buffered saline-soluble filariform larval antigens in eight Jamaican patients treated with ivermectin. Patients were followed for periods of between 170 and 542 days. Based on repeated formalin-ether concentration and agar plate culture, all patients were found to be uninfected up to 18 months following chemotherapy. Generally, all antibody isotype levels decreased following treatment, although there was considerable heterogeneity among patients. In a single patient with hyperinfection, the decrease in IgG4 was marginal and may represent a treatment failure. Reduction in serum antibody isotype responses to S. stercoralis following treatment may be used to assess the effectiveness of ivermectin in treating endemic strongyloidiasis.....
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Keywords
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