Campbell, Sacha; Alexander-Lindo, Ruby; McGrowder, Donovan A.; Gordon, L.; Dasgupta, Tara
Author Affiliation, Ana.
The Effect of S-Nitrosocaptopril and S-Nitroso-N-Acetyl-D,L-penicillamine on glucose concentration and haemodynamic parameters.
Journal of Applied Biomedicine
Date of Publication
Studies have shown that S-nitrosothiols (RSNOs) are able to affect glucose metabolism and blood pressurein animal models. This paper describes an investigation into the effect of two RSNOs, S-nitrosocaptopril(CapSNO) and S-nitroso-N-acetyl-D,L-penicillamine (SNAP) on fasting and postprandial blood glucoseconcentration, and systolic and diastolic blood pressures. Rats administered intravenously with CapSNO andSNAP, using dosages of 2.0, 5.0 and 12.5 mg/kg BW, showed a dose-dependent hyperglycaemic effect.Intravenous administration of 12.5 mg/kg BW of CapSNO and SNAP caused a statistically significant increasein fasting blood glucose concentration compared to rats treated with the same dosage of captopril.SNAP-treated rats showed a significantly greater elevation of fasting (F2) blood glucose concentration (5.91 ±0.27 mmol/l) compared to CapSNO-treated rats (5.11 ± 0.08 mmol/l. However there was no significantdifference in postprandial blood glucose concentrations. SNAP, CapSNO and captopril significantly reducedboth systolic and diastolic blood pressures. This was accompanied by an increase in heart rate. Theanti-hypertensive property of CapSNO and SNAP was more significant than that of captopril. CapSNO wasmore potent than SNAP in reducing blood pressure, suggesting that CapSNO may act via a combinedmechanism that involves ACE inhibition and NO release.....