Smikle, Monica ; Barton, Everard N.; DeCeulaer, Karel; Williams, Winston; James, Owen B.
Author Affiliation, Ana.
Systemic lupus erythematosus, rheumatoid arthritis and HLA phenotypes in Jamaicans.
West Indian Medical Journal
Date of Publication
The HLA phenotypes were investigated in 30 Jamaican patients with systemic lupus erythematosus (SLE), 30 with rheumatoid arthritis (RA) and 40 healthy controls. HLA phenotypes were determined by the microcytoxicity technique, using commercially prepared typing trays. The HLA phenotypic associations with SLE (HLA-B14, RR 4.3: HLA-A28, RR 4.3) were not statistically significant. However, a statistically significant lack of HLA-A9 (p<0.01;CP<0.1) was observed in SLE patients compared to healthy controls. In RA patients, a statistically significant association was noted with HLA-A2 (RR5.1; CP<0.01). No HLA class II associations were noted with SLE. Class II associations with RA did not achieve statistical significance but included those previously established in other populations. The preliminary data obtained indicate differences in the patterns of HLA phenotypes in Jamaican patients with SLE and RA, compared to those observed in such patients elsewhere.....