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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Conway, David J; Lindo, John F; Robinson, Ralph, D.; Bundy, Donald A. P; Bianco, Albert E.
Author Affiliation, Ana.
Microbiology; Basic Medical Sciences (Anatomy, Biochemistry, Physiology)
Article Title
Strongyloides stercoralis: Characterization of immunodiagnostic larval antigens.
Medium Designator
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Connective Phrase
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Journal Title
Experimental Parasitology
Translated Title
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Reprint Status
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Date of Publication
1994
Volume ID
79
Issue ID
2
Page(s)
99-105
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Forty-one-, 31-, and 28-k Da proteins of Strongyloides stercoralis filariform larvae have previously been demonstrated to be sensitively and specifically recognized by serum IgG in individuals with strongyloidiasis. Characteristics of these proteins, their immunodominant epitopes, and reactive antibodies are described. The proteins are soluble in aqueous as well as detergent extracts. The immunodominant epitopes are present in S. stercoralis but not in S. cebus or S. ratti. Epitopes on the three proteins are not shared, as determined by cross-adsorption of serum with each of the size components on nitrocellulose. In most sera from strongyloidiasis patients there was reactivity to each of the proteins by IgG1 and IgG4, but reactivity by IgG2 or IgG3 was detectable only in a minority. A rabbit antiserum raised to a 41-kDa size fraction of S. stercoralis larvae reacted against a doublet of 41-kDa that was distinct from the immunodiagnostic 41-kDa protein.....
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Keywords
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