Bennett,Franklyn I.; McFarlane-Anderson,Norma; Wilks, Rainford J.; Luke, Amy; Cooper, Richard S.; Forrester, Terrence E.
Author Affiliation, Ana.
Leptin concentration in women is influenced by regional distribution of adipose tissue
American Journal of Clinical Nutrition
Date of Publication
This study was undertaken to determine whether anthropometric factors influenced leptin concentrations in our population. Leptin concentrations were measured in 375 persons from a population study of hypertension and diabetes for whom body-composition data (bio-electrical impedance analysis and anthropometry) were available. Serum leptin concentrations were more than four times higher in women than in men (18.5 ± 13.9 compared with 3.8 ± 3.6 ng/L, P < 0.0001). In individuals with comparable body mass indexes, these differences persisted after adjustment for either percentage fat (P < 0.05) or fat mass (P < 0.0001) by multivariate-regression analysis. After fat mass was adjusted for, the serum leptin concentration in both men and women was independent of waist circumference but in women was associated with hip circumference. Hip circumference is a proxy measure of peripheral fat and these results suggest that the larger hips of women may contribute to the sex difference in serum leptin concentration....