Atkins, Neil S.; Lindo, John F.; Lee, Michael G.; Conway, David J.; Bailey, J.W.; Robinson, Ralph, D.; Bundy, Donald A. P.
Author Affiliation, Ana.
Microbiology; Life Sciences (Botany and Zoology); Faculty of Pure and Applied Sciences
Humoral responses in human strongyloidiasis: Correlation with infection chronicity
Transactions of the Royal Society of Tropical Medicine and Hygiene
Date of Publication
Compares Strongyloides stercoralis L3-specific antibody isotype responses among individuals with known long-standing (28-46 years) infection with those of 'young' (6-29 years of age) and 'old' (30-80 years of age) infected individuals from an endemic Jamaican population. Suggests that age correlates with infection chronicity in communities endemic for S. stercoralis, and that individuals acquire infection early in their lives and remain infected into adulthood. Early and sustained upregulation of IgG4 may facilitate the establishment of infection and, in combination with developing IgE hypo-responsiveness, may promote chronic asymptomatic strongyloidiasis. Conversely, upregulated IgA may be involved in controlling chronic infection levels that are reflected in reduced IgG1 production.....