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Publication Type
Journal Article
Author, Analytic
Manns, Angela; Hanchard, Barrie; Morgan, Owen St. C.; Wilks, Rainford J.; Cranston, Beverley; Nam, Jun-mo; Blank, Michelle; Kuwayama, Masahiro; Yashiki, Shinji; Fujiyoshi, Toshinobu; Blattner, William A.; Sonoda, Shunro
Author Affiliation, Ana.
Pathology
Article Title
Human leukocyte antigen class II alleles associated with human T cell lymphotropic virus type I infection and adult T-cell leukemia/lymphoma in a black population.
Medium Designator
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Connective Phrase
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Journal Title
Journal of the National Cancer Institute
Translated Title
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Reprint Status
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Date of Publication
1998
Volume ID
90
Issue ID
8
Page(s)
617-622
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
Analyses HLA class II alleles among asymtomatic HTLV-I carriers (n=45), patients with ATL (n=49) or HAM/TSP (n=54), and HTLV-I seronegative control subjects (n=51). All participants were of African descent and were enrolled in epidemiological ctudies conducted at the University of the West Indies, Kingston, Jamaica. Standard microlymphocytotoxicity asays for HLA serotyping and polymerase chain reaction-based methods were used to examine HLA class II DRB1 and DQB1 alleles. Two antigens determined by serotyping, DR15 and DQ1, occurred at significantly increased frequency among the HTLV-I carriers compared with sero-negative control subjects (42% versus 22% for DR15 [odds ratio {OR} = 2.7; 95% confidence interval {CI} = 1.0 - 7.2] and 78% versus 53% for DQ1 [OR = 3.1; 95% CI = 1.2-8.5]). Asymptomatic carriers were shown to have an HLA class II allele distibution similar to that of patients with ATL, and the frequencies of the alleles DRB1*1501, DRB1*1101, and DQB1*0602 were significantly greater in patients with ATL and asymptomatic carriers than in patients with HAM/TSP. In addition haplotypes DRB1*1101- DQB1*0301 and CRB1*1501- DQB1*0602 were significantly increased among patients with ATL compared with patients with HAM/STP. These data suggest that host genetic background is an important factor in determining whether HTLV-1 carriers develop either ATL or HAM/TSP.....
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Keywords
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