Wilks, Rainford J.; La Grenade, Lois; Hanchard, Barrie; Campbell, Marie A.; Murphy, Jacquelyn J.; Cranston, Beverley; Blattner, William A.; Manns, Angela
Author Affiliation, Ana.
Tropical Metabolism Research Unit
Sibling adult T-cell leukemia/lymphoma and clustering of human T-Cell lymphotropic virus type I infection in a Jamaican family
Date of Publication
Familial ATL has not previously been reported from Jamaica. Hospital records and histologic specimens of the two cases were reviewed. HTLV-I infection was confirmed by antibody testing and by polymerase chain reaction on paraffin-embedded tissue, where serum was unavailable. Family members were identified by the patient's parents. After giving informed consent, family members were asked to complete an interviewer-administered questionnaire and to agree to phlebotomy. ATL developed 10 years apart in two siblings from a family at age 16 and 24 years. A study of 19 members of their extended family, including both parents, 2 grandparents, and 3 siblings, revealed an overall HTLV-I seroprevalence of 17%. This compared with 75% among parents and siblings living in the same household as the patients....