Strickler, Howard D.; Escoffery, Carlos T.; Rattray, Carole A; Fuchs, Dietmar; Wachter, Helmut; Manns, Angela; Schiffman, Mark H.; Cranston, Beverley; Hanchard, Barrie; Blattner, William A.
Author Affiliation, Ana.
Pathology; Obstetrics, Gynaecology and Child Health
Cervical intraepithelial neoplasia is not associated with elevated serum neopterin levels.
Cancer Epidemiology, Biomarkers and Prevention
Date of Publication
Neopterin, a marker of cellular immune activation, was elevated in patients who had cervical cancer in previous studies. To examine neopterin in the presence of precursors to cervical cancer (i.e. cervical intraepithelial neoplasia) serum levels were measured in 185 colposcopy patients in Jamaica, a country with high cervical cancer incidence, and in 72 age-matched Jamaican women selected from a large population-based sample. Serum levels of ß-2 -microglobulin, another commonly used marker of immune activation, were also measured. Neopterin and ß-2 -microglobulin levels were not elevated in colposcopy patients; neither were they related to severity of cervical neoplasia. In multivariable analysis, neither adjustments for detection of cervical human papillomavirus DNA by PCR nor detection of antibodies to human T-cell lymphotropic virus type 1 (a retrovirus endemic to Jamaica) altered the findings. The absence of a serologically detectable increase in cellular immune activation linked to cervical intraepithelial neoplasia does not involve susbtantial systemic immune activation.....