Author Affiliation, Ana.
Clinical manifestations of HTLV-1 infection.
Postgraduate Doctor - Caribbean
Date of Publication
Adult T-cell leukaemia/lymphoma (ATL) and tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) are the major clinical manifestations of HTLV-1 infection in adults. Susceptibility is related not only to the mode and age of acquisition of the virus but also to genetic, socio-economic and geographic factors. Recently there has been documentation of a number of other disease associations in adults including: polymyositis, uveitis, arthropathy, cystitis and prostatitis. These diseases which exhibit an autoimmune mode of pathogenesis underscore the widespread systemic effects of the virus. In childhood infective dermatitis is a specific marker for HTLV-1 infection with a risk of evolution into either ATL or TSP/HAM in adult life.....