Douglas, Lawson L.
Author Affiliation, Ana.
Surgery, Radiology, Anaesthesia and Intensive Care
Prostate cancer and PSA: A practitioner's perspective.
Postgraduate Doctor - Caribbean
Date of Publication
Cancer of the prostate is the commonest malignant tumour in the male. Although it exhibits a wide range of biological activity, in its late stages considerable morbidity may occur with eventual death. Early diagnosis before the tumour has spread beyond the capsule allows cure by radical prostatectomy or ablative radiotherapy. Prostate specific antigen (PSA) is a sensitive biochemical marker which although not specific for prostate cancer is elevated in 90% of cases with this disease. Specificity in the diagnosis of prostate cancer has been increased by using the principles of PSA density, PSA velocity, and age differential PSA normal values. If digital rectal examination (DRE) is combined with PSA testing the detection rate of early prostate cancer is greatly increased. When either the PSA is elevated or the DRE is suspicious the diagnosis should be confirmed by transrectal ultrasonography (TRUS) and biopsy.....