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Publication Type
Journal Article
Author, Analytic
Jackson, M. D.; Tulloch-Reid, M. K.; McFarlane-Anderson, N.; Watson, A.; Seers, V.; Bennett, F. I.; Egleston, B.; Ragin, C.
Author Affiliation, Ana.
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Article Title
Complex interaction between serum folate levels and genetic polymorphisms in folate pathway genes: biomarkers of prostate cancer aggressiveness
Medium Designator
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Connective Phrase
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Journal Title
Genes Nutr
Translated Title
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Reprint Status
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Date of Publication
2013
Volume ID
8
Issue ID
2
Page(s)
199-207
Language
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Connective Phrase
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Location/URL
http:; www.ncbi.nlm.nih.gov/pmc/articles/PMC3575883/
ISSN
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Notes
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Abstract
Little is known about the role of folate and polymorphisms associated with folate metabolism on prostate cancer risk in populations of African origin. We examined the relationship between serum folate and prostate cancer and whether any association was modified by genetic polymorphisms for folate metabolism. The study was case-control in design and consisted of 218 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 236 cancer-free men attending the same urology clinics in Jamaica, March 2005-July 2007. Serum folate was measured by an immunoassay method and genomic DNA evaluated for MTHR (C677T and A1298C), MTRR A66G, and MTR A2756G polymorphisms. Mean serum folate concentration was higher among cases (12.3 4.1 nmol/L) than controls (9.7 4.2 nmol/L). Serum folate concentration showed a positive association with prostate cancer (OR, 4.41; CI, 2.52-7.72 per 10 nmol/L) regardless of grade. No interactions were observed between genotype and folate concentration, but a weak gene effect was observed for MTHFR A1298C and low-grade prostate cancer. Larger studies to investigate the role of gene-gene/gene-diet interactions in Black men are needed.....
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Keywords
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