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Publication Type
Journal Article
Author, Analytic
Lowe, Henry I. C.; Watson, Charah T.; Badal, Simone; Toyang, Ngeh J.; Bryant, Joseph
Author Affiliation, Ana.
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Article Title
Kinase inhibition of the Jamaican ball moss, Tillandsia recurvata, L.
Medium Designator
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Connective Phrase
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Journal Title
Anticancer Research
Translated Title
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Reprint Status
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Date of Publication
2012
Volume ID
32
Issue ID
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Page(s)
4419-4422
Language
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Connective Phrase
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Location/URL
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ISSN
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Notes
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Abstract
BACKGROUND: This research was undertaken in order to investigate the inhibitory potential of the Jamaican ball moss, Tillandsia recurvata against several kinases. The inhibition of these kinases has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation. MATERIALS AND METHODS: Kinase inhibition was investigated using competition binding (to the ATP sites) assays, which have been previously established and authenticated. RESULTS: Four hundred and fifty one kinases were tested against the Jamaican ball moss extract and a dose-response was tested on 40 kinases, which were inhibited by more than 35% compared to the control. Out of the 40 kinases, the Jamaican ball moss selectively inhibited 5 (CSNK2A2, MEK5, GAK, FLT and DRAK1) and obtained Kd(50)s were below 20 ?g/ml. CONCLUSION: Since MEK5 and GAK kinases have been associated with aggressive prostate cancer, the inhibitory properties of the ball moss against them, coupled with its previously found bioactivity towards the PC-3 cell line, makes it promising in the arena of drug discovery towards prostate cancer.....
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Keywords
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