View
Publication Type
Conference Proceedings
Author, Analytic
Badaloo, A; Green, C.; HSU, J.; Taylor-Bryan, C.; Reid, M.; Forrester, T.; Jahoor, F.
Author Role
n/a
Author Affiliation
n/a
Paper/Section Title
Effects of methionine supplementation on cysteine and glutathione production in oedematous malnourished children
Medium Designator
n/a
Connective Phrase
n/a
Editor/Compiler
n/a
Editor/Compiler Role
n/a
Proceedings Title
58th Annual Scientific Meeting of the Caribbean Public Health Agency
Date of Meeting
2013
Place of Meeting
Barbados
Place of Publication
n/a
Publisher Name
n/a
Date of Publication
n/a
Date of Copyright
n/a
Volume ID
n/a
Location in Work
n/a
Extent of Work
n/a
Packaging Method
n/a
Series Editor
n/a
Series Editor Role
n/a
Series Title
n/a
Series Volume ID
n/a
Location/URL
n/a
ISBN
n/a
Notes
n/a
Abstract
A shortage of cysteine (CYS) is associated with low glutathione (GSH) synthesis in edematous childhood severe acute malnutrition (SAM). We investigated the effect of isonitrogenous (0.6 mmol/kg/d) supplementation of CYS precursor, methionine, (MET, n = 6) versus alanine (ALA, n = 6) as control on endogenous CYS production and erythrocyte GSH synthesis in edematous SAM. Measurements were made in children aged 8.8 ± 2.6 months 3 times during early treatment for SAM with infection using constant, intravenous infusions of stable isotopes of MET at ~ 2d (Stage 1),~7d, (Stage 2), and ~14 d(Stage 3) after admission. Stage 1 Stage 2 Stage 3 ALA MET ALA MET ALA MET GSH ASR (mmol/l/d) CYS Kinetics (?mol/kg/h) 0.3 ± 0.1 0.2 ± 0.04 0.6 ± 0.08 0.6 ± 0.2 0.9 ± 0.6 0.9 ± 0.1 Dietary inflow 6.9 ± 0.2 7.3 ± 0.2 6.3 ± 0.02 6.4 ± 0.02 6.4 ± 0.02 6.3 ± 0.04 Total flux 41.3 ± 5.8 41.1 ± 7.9 44.95 ± 3.9 54.6 ± 4.6 49.7 ± 3.5 50.7 ± 3.6 Denovo Synthesis 11.8 ± 2.5 12.5 ± 2.1 10.0 ± 0.9 8.6 ± 1.4 8.5 ± 1.1 8.4 ± 1.6 Protein derived flux 21.1 ± 3.5 19.8 ± 6.8a 27.1 ± 3.1 38.15 ± 4.2 33.4 ± 2.5 34.5 ± 2.5 Mean ± SEM. ASR absolute synthesis rate; a different from stages 2 and 3 in MET group, (p < 0.05) MET supplementation stimulated CYS supply from protein breakdown but did not significantly increase GSH synthesis. The increase in CYS supply might have contributed to CYS rich proteins associated with infection such as acute phase proteins.....
read more
Keywords
n/a