Levy, Arkene S
Author Affiliation, Ana.
Role of TMPRSS2-ERG Fusions in Prostate Cancer: Significance of Assessment in Jamaican Men
West Indian Medical Journal
Date of Publication
Epub ahead of print. DOI:10.7727/wimj.2015.574
Prostate cancer is the leading cancer affecting men in Jamaica and is also the leading cause of male cancer-related deaths in Jamaica. This high mortality rate is primarily attributable to the eventual development of metastatic castration resistant prostate cancer which is challenging to treat. This paper discusses the pathological roles of the TMPRSS2 and ERG genes which are highly expressed in prostate cancer when compared to other cancer types. The presence of the TMPRSS2-ERG gene fusion transcript is linked to progression, metastasis and androgen regulated changes in castration resistant prostate cancer; but the status of these biomarkers have not been previously evaluated in Jamaican men with prostate cancer. The significance and implications of such an assessment is discussed herein.....