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Publication Type
Journal Article
Author, Analytic
Boyne, Michael S; Thompson, Debbie S; Osmond, C; Ferguson, Trevor S; Tulloch-Reid, Marshall K; Wilks, Rainford J; Barnett, AT; Forrester, Terrence E
Author Affiliation, Ana.
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Article Title
Fasting indices do not correlate with dynamic measures of insulin sensitivity in Afro-Caribbean adults
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Date of Publication
2014
Volume ID
7
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Page(s)
98
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Abstract
Insulin sensitivity can be estimated using glucose disposal rate (M) measured during a hyperinsulinemic euglycemic clamp (HEC) or insulin sensitivity index (SI) derived from a frequently sampled intravenous glucose tolerance test (FSIVGTT). The commonly used homeostatic model assessment of insulin resistance (HOMA-IR) which utilizes fasting glucose and insulin has been validated against M across several populations (r?=?0.5-0.8). This study sought to validate HOMA-IR against SI and M in an Afro-Caribbean population.FindingsSixty participants completed a 180-minute FSIVGTT and another 50 completed a 150-minute hyperinsulinemic euglycemic clamp. In both groups, HOMA-IR was calculated and anthropometry and body composition using dual energy x-ray absorptiometry (DEXA) were measured.FSIVGTT: The participants were 55% male, age 23.1??0.05 years, BMI 24.8??6.3 kg/m2 and % body fat 25.0??15.2 (mean??SD). HEC: The participants were 44% male, age 27.3??8.1 years, BMI 23.6??5.0 kg/m2 and % body fat 24.7??14.2 (mean??SD). While HOMA-IR, SI and M correlated with waist, BMI and % body fat (P-values??0.2).ConclusionsIn young Afro-Caribbean adults, HOMA-IR compared poorly with other measures of insulin sensitivity. It remains important to determine whether similar findings occur in a more insulin resistant population. However, HOMA-IR correlated with clinical measures of insulin sensitivity (i.e. adiposity), so it may still be useful in epidemiological studies.....
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